Endocrine Abstracts

Background: Diabetes is a risk factor for both PAD and PAD-associated mortality. Diabetic patients have worse arterial disease and a poorer outcome than nondiabetic patients. Fetuins are blood proteins made in the liver more abundant in fetal blood. Fetuin-A is regarded as an inhibitor of systemic calcification.Aim of this work: To assess the relationship between plasma fetuin-A levels and peripheral vascular disease in type 2 diabetes mellitus.<p cl...

Background: There is accumulating evidence suggesting that altered vitamin D may play a role in the development of T2DM. A growing body of evidence suggests that low levels of vitamin D may adversely affect the cardiovascular system.Objective: This is to assess the relation of serum 25 OH vitamin D concentrations and risk of CVD in T2DM patients.Subjects and methods: Seventy subjects aged from 40 to 60 years were chosen excluding t...

Background: Chronic kidney disease secondary to type 2 diabetes is associated with multifactorial energy dysmetabolism. Irisin has been identified recently as an exercise induced hormone secreted by skeletal muscles. It is hypothesised that patients with CKD may have altered irisin levels.Aim of the work: We aimed to study irisin hormone in type 2 diabetic patient and to assess its relation with diabetic nephropathy (DN).Subjects a...

Introduction: Egypt has an epidemic of HCV. Interferon (IFN) is the drug of choice for treatment induces autoimmune thyroiditis. The biochemical characteristic of the autoimmune thyroid disorder is the presence of autoantibodies against thyroid peroxidase and thyroglobulin. Chemokine ligand 10 (CXCL10) is an IFN inducible chemokine involved in the autoimmune thyroid disease.Aim: To assess the incidence of autoimmune thyroid disorder following treatment w...

Background: Vascular endothelial growth factor (VEGF) is involved in endothelial dysfunction in hypertension and diabetes. It may play a role in the pathogenesis of diabetic nephropathy and retinopathy. Other various growth factors were found to be involved in the neovascularization in proliferative diabetic retinopathy including insulin like growth factor -1 (IGF-1) but most of the studies have measured only a single growth factor especially in the vitreous fluid, thus ignori...

Objective: Assess the effect of bariatric surgery on serum glucagon like peptide-1 (GLP-1) concentration and metabolic and biochemical parameters pre and postoperatively.Methods: This prospective study comprised 50 subjects divided into 3 groups. Group 1: 20 obese subjects with T2DM (BMI >35) that underwent Roux-en-y gastric bypass surgery; Group 2: 20 lean subjects with T2DM and Group 3: 10 lean subjects as healthy controls.Bo...

Background: Visceral fat-derived protein named visfatin was discovered in 2005. Visfatin may improve glucose tolerance, and its plasma levels correlate strongly with the amount of visceral adipose tissue in humans. Visfatin has insulin-like metabolic effects on glucose metabolism but has a distinct binding site on insulin receptors. These findings triggered great interest for many researchers to explore the mechanism(s) of regulation of visfatin expression, and the possible re...